Acute oral toxicity evaluation of Andrographis paniculata-standardized first true leaf ethanolic extract
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چکیده
منابع مشابه
Hepatoprotective potential of Andrographis paniculata aqueous leaf extract on ethanol . induced liver toxicity in albino rats
To investigate the protective effect of the leaf extract of Andrographis paniculata (Ap) against ethanol induced liver toxicity in male albino rats. The liver toxicity was induced by the administration of ethanol to the animals at the optimum dosage of 7.9g/kg body wt., orally for 45 days. After induction of liver toxicity the aqueous plant extract of A.p was administered to the animal 250 mg/k...
متن کاملEvaluation of the antinociceptive activity and acute oral toxicity of standardized ethanolic extract of the rhizome of Curcuma xanthorrhiza Roxb.
Ethanolic extract of Curcuma xanthorrhiza was used to evaluate the analgesic and toxicity effects in vivo. The extract was standardized using GC-MS, which showed that 1 mg of Curcuma xanthorrhiza ethanolic extract contains 0.1238 mg of xanthorrhizol. The analgesic activity was studied in rats using three different models, namely the hot plate test, tail flick test and formalin-induced pain test...
متن کاملIn vitro anti oxidant activity and acute oral toxicity of Terminalia paniculata bark ethanolic extract on Sprague Dawley rats.
OBJECTIVE To ensure the safety and evaluate the anti oxidant activity of Terminalia paniculata (T. paniculata) ethanolic extract in Sprague Dawley rats. METHODS The solvent extracts (hexane, ethyl acetate and ethanol) of T. paniculata were subjected to phytochemical analysis and their DPPH radical scavenging activity was assayed. The oral acute toxicity was evaluated using ethanolic extract o...
متن کاملIs Andrographis paniculata extract and andrographolide anaphylactic?
Andrographis paniculata, "King of bitters" is a popularly known medicinal plant extensively used in many parts of the world for treatment of various diseases. Since recent past, anaphylactic/allergic type adverse events were reported upon A. paniculata usage, the study aimed to evaluate the anaphylactic and anaphylactoid potential of A. paniculata extract and andrographolide (a major phytoactiv...
متن کاملEffect of Andrographis paniculata leaf extract on wound healing in rats.
This work was carried out to study the effect of topical application of Andrographis paniculata on the rate of wound enclosure and its histological features. A wound was created in four groups of rat in posterior neck region. Blank placebo was applied topically to the wounds of Group 1. Groups 2 and 3 were dressed with placebo containing 5% and 10% extracts of A. paniculata, respectively. Intra...
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ژورنال
عنوان ژورنال: Toxicology Reports
سال: 2019
ISSN: 2214-7500
DOI: 10.1016/j.toxrep.2019.05.003